Pubblicazioni - 2002/2004

Amendola A., Fesus L., Piacentini M., Szondy, Z. (2002) "Tissue" transglutaminase in AIDS. J. Immunol. Methods, 265, 145-59.

Amicone L., Terradillo O., Calvo L., Costabile B., Cicchini C., Della Rocca C., Lozupone F., Piacentini M., Buendia M.A., Tripodi M. (2002) Synergy between truncated c-Met (cyto-Met) and c-Myc in liver oncogenesis: importance of TGF-beta signalling in the control of liver homeostasis and transformation. Oncogene, 21, 1335-45.

Castedo M., Roumier T., Blanco J., Ferri K.F., Barretina J., Tintignac L.A., Andreau K., Perfettini J.L., Amendola A., Nardacci R., Leduc P., Ingber D.E., Druillennec S., Roques B., Leibovitch S.A., Vilella-Bach M., Chen J., Este J.A., Modjtahedi N., Piacentini M., Kroemer G. (2002) Sequential involvement of Cdk1, mTOR and p53 in apoptosis induced by the HIV-1 envelope. Embo J,, 21, 4070-80.

Di Sano F., Di Bartolomeo S., Fazi B., Fiorentini C., Matarrese P., Spinedi A., Piacentini M. (2002) Antisense to glucosylceramide synthase in human neuroepithelioma affects cell growth but not apoptosis. Cell Death Differ., 9, 693-5.

Fesus L., Piacentini, M. (2002) Transglutaminase 2: an enigmatic enzyme with diverse functions. Trends Biochem. Sci., 27, 534-9.

Lovat P.E., Oliverio S., Ranalli M., Corazzari M., Rodolfo C., Bernassola F., Aughton K., Maccarrone M., Hewson Q.D., Pearson A.D., Melino G., Piacentini M., Redfern, C.P. (2002) GADD153 and 12-lipoxygenase mediate fenretinide-induced apoptosis of neuroblastoma. Cancer Res., 62, 5158-67.

Mastroberardino P.G., Iannicola C., Nardacci R., Bernassola F., De Laurenzi V., Melino G., Moreno S., Pavone F., Oliverio S., Fesus L., Piacentini, M. (2002) 'Tissue' transglutaminase ablation reduces neuronal death and prolongs survival in a mouse model of Huntington's disease. Cell Death Differ., 9, 873-80.

Piacentini M., Farrace M.G., Piredda L., Matarrese P., Ciccosanti F., Falasca L., Rodolfo C., Giammarioli A.M., Verderio E., Griffin M., Malorni, W. (2002) Transglutaminase overexpression sensitizes neuronal cell lines to apoptosis by increasing mitochondrial membrane potential and cellular oxidative stress. J. Neurochem., 81, 1061-72.

Rodolfo C., Piacentini M. (2002) Does cytoskeleton 'Akt' in apoptosis? Cell Death Differ., 9, 477-8.

Lentini A.,Beninati S. (2002) Differentiation therapy of cancer: transglutaminase as diffentiative tool. Minerva Biotecnologica, 14, 159-164.

Facchiano F., Lentini A, Mennella C., Fogliano V. (2002) In vivo glycation of fibroblast growth factor. In: Melanoidins in Food and Health,Vol. 3 (Fogliano V., Henle T. Eds.), Office for Official Publications of the European Communities, Luxembourg, 225-231.

De Marchis F., Ribatti D., Giampietri C., Lentini A., Faraone D., Scoccianti M., Capogrossi M.C., Facchiano A. (2002) Platelet-derived growth factor inhibits basic fibroblast growth factor angiogenic properties in vitro and in vivo through its alpha receptor. Blood, 99, 2045-2053.

Caraglia M., Marra M., Giuberti G., D’Alessandro A.M., Beninati S., Lentini A., Pepe S., Boccellino M., Abbruzzese A. (2002) Theophylline-induced apoptosis is paralleled by protein kinase A-dependent tissue transglutaminase activation in cancer cells. J. Biochem., 132, 45-52.

Facchiano F., Lentini A., Fogliano V., Mancarella S., Rossi C., Facchiano A., Capogrossi M.C. (2002) Sugar-induced modification of fibroblast growth factor 2 reduces its angiogenic activity in vivo. Am. J. Pathol.., 161, 531-541.

Candé C., Cecconi F., Dessen Ph., Kroemer G. (2002) Apoptosis inducing factor (AIF): key to the conserved caspase-independent pathways of cell death? J. Cell Sci., 115, 4727-4734.

Marsden V., O’Connor L., Huang D.C.S., Metcalf D., Cecconi F., Kuida K., Tomaselli K., Silke J., Vaux D.L., O’Reilly L.A., Bouille P., Adams J.M., Strasser A. (2002) Apoptosis regulated by Bcl-2 inhibition of caspase activation upstream of Apaf-1 and caspase-9. Nature, 419, 634-637.

Cregan S.P., Fortin A., MacLaurin J.G., Callaghan S.M., Cecconi F., Park D.S., Dawson T.M., Kroemer G., Slack R.S. (2002) Apoptosis Inducing Factor Regulates Caspase-independent neuronal cell death. J. Cell. Biol., 158, 507-517.

Matsuki Y., Zhang H., Hsu H., Yang P., Zhou T., Dodd C., Cecconi F., Gruss P., Tadakuma T. Mountz J. (2002) Different Role of Apaf-1 in Positive Selection, Negative Selection and Death by Neglect in Foetal Thymic Organ Culture. Scand. J. Immunol., 56, 174-184.

Bitzer M., Armeanu S., Prinz F., Ungerechts G., Wybranietz W., Spiegel M., Bernlöhr C., Cecconi F., Gregor M., Neubert W.J., Schulze-Osthoff K., Lauer U.M. (2002) Caspase-8 and Apaf-1 independent caspase-9 activation in Sendai virus infected cells. J. Biol. Chem., 277, 29817-29824.

O’Reilly L. A., Harvey N., Marsden V., Cullen L., Vaux D.L., Haecker G., Ekert P., Magnusson C., Pakusch M., Cecconi F., Kuida K., Strasser A., Kumar S., Huan, D.C.S. (2002) Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is mediated by Apaf-1 and caspase-9. Cell Death Differ., 9, 832-841.

Heins N., Malatesta P., Cecconi F., Nakafuku M., Tucker K.L., Hack M.A., Chapouton P., Barde Y.A., Gotz M. (2002) Glial cells generate neurons: the role of the transcription factor Pax6. Nat. Neurosci., 5, 308-315.

Moreno S., Ferraro E., Eckert S., Cecconi F. (2002) Apaf1 reduced expression levels generate a mutant phenotype in adult brain and skeleton. Cell Death Differ., 9, 340-342.

Castedo M., Perfettini J.L., Andreau K., Roumier T., Piacentini M., Kroemer, G. (2003) Mitochondrial apoptosis induced by the HIV-1 envelope. Ann. N. Y. Acad. Sci., 1010, 19-28.

Corazzari M., Lovat P.E., Oliverio S., Pearson A.D., Piacentini M., Redfern C.P. (2003) Growth and DNA damage-inducible transcription factor 153 mediates apoptosis in response to fenretinide but not synergy between fenretinide and chemotherapeutic drugs in neuroblastoma. Mol. Pharmacol., 64, 1370-8.

Di Sano F., Fazi B., Citro G., Lovat P.E., Cesareni G., Piacentini M. (2003) Glucosylceramide synthase and its functional interaction with RTN-1C regulate chemotherapeutic-induced apoptosis in neuroepithelioma cells. Cancer Res., 63, 3860-5.

Falasca L., Ciccosanti F., Nardacci R., Antonucci G., Piacentini M. (2003) Trying to catch the HCV virus in its 'battle field'. Cell Death Differ., 10 Suppl 1, S77-8.

Lovat P.E., Oliverio S., Corazzari M., Ranalli M., Pearson A.D., Melino G., Piacentini M., Redfern C.P. (2003) Induction of GADD153 and Bak: novel molecular targets of fenretinide-induced apoptosis of neuroblastoma. Cancer Lett., 197, 157-63.

Lovat P.E., Oliverio, S., Corazzari, M., Rodolfo, C., Ranalli, M., Goranov, B., Melino, G., Redfern, C.P. and Piacentini, M. (2003) Bak: a downstream mediator of fenretinide-induced apoptosis of SH-SY5Y neuroblastoma cells. Cancer Res., 63, 7310-3.

Lovat P.E., Ranalli M., Corazzari M., Raffaghello L., Pearson A.D., Ponzoni M., Piacentini M., Melino G., Redfern, C.P. (2003) Mechanisms of free-radical induction in relation to fenretinide-induced apoptosis of neuroblastoma. J. Cell Biochem., 89, 698-708.

Nardacci R., Ciccosanti F., Falasca L., Lo Iacono O., Amendola A., Antonucci G., Piacentini M. (2003) Tissue transglutaminase in HCV infection. Cell Death Differ., 10 Suppl 1, S79-80.

Nardacci R., Lo Iacono O., Ciccosanti F., Falasca L., Addesso M., Amendola A., Antonucci G., Craxi A., Fimia G.M., Iadevaia V., Melino G., Ruco L., Tocci G., Ippolito G., Piacentini, M. (2003) Transglutaminase type II plays a protective role in hepatic injury. Am. J. Pathol., 162, 1293-303.

Piacentini M., Evangelisti C., Mastroberardino P.G., Nardacci R., Kroemer, G. (2003) Does prothymosin-alpha act as molecular switch between apoptosis and autophagy? Cell Death Differ., 10, 937-9.

Romagnoli A., Oliverio S., Evangelisti C., Iannicola C., Ippolito G., Piacentini, M. (2003) Neuroleukin inhibition sensitises neuronal cells to caspase-dependent apoptosis. Biochem. Biophys. Res. Commun., 302, 448-53.

Szondy Z., Sarang Z., Molnar P., Nemeth T., Piacentini M., Mastroberardino P.G., Falasca L., Aeschlimann D., Kovacs J., Kiss I., Szegezd, E., Lakos G., Rajnavolgyi E., Birckbichler P.J., Melino G., Fesus, L. (2003) Transglutaminase 2-/- mice reveal a phagocytosis-associated crosstalk between macrophages and apoptotic cells. Proc. Natl .Acad. Sci .U S A, 100, 7812-7.

D’Sa C., Klocke B.J., Cecconi F., Lindsten T., Thompson C.B., Korsmeyer S.J., Flavell, R.A., Roth, K.A. (2003) Caspase regulation of genotoxin-induced neural precursor cell death. J. Neurosci. Res., 74, 435–445.

Arnoult D., Gaume B., Karbowski M., Sharpe J.C., Cecconi F., Youle R. J. (2003) Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization. Embo J., 22, 4385-4399.

Ferraro E., Corvaro M., Cecconi F. (2003) Physiological and pathological roles of the apoptosome. J. Cell. Mol. Med., 7, 21-34.

Beninati S., Piacentini M. (2004) The transglutaminase family: an overview: minireview article. Amino Acids, 26, 367-72.
Cecconi F., Roth K.A., Dolgov O., Munarriz E., Anokhin K., Gruss P., Salminen M. (2004) Apaf1-dependent programmed cell death is required for inner ear morphogenesis and growth. Development, 131, 2125-2135.

Bordoni V., Alonzi T., Agrati C., Poccia F., Borsellino G., Mancino G., Fimia G.M., Piacentini M., Fantoni A., Tripodi, M. (2004) Murine hepatocyte cell lines promote expansion and differentiation of NK cells from stem cell precursors. Hepatology, 39, 1508-16.

D'Argenio G., Farrace M.G., Cosenza V., De Ritis F., Della Valle N., Manguso F, Piacentini M. (2004) Expression of apoptosis-related proteins in rat with induced colitis. Int .J .Colorectal. Dis.., 19, 451-60.

Fimia G.M., Evangelisti C., Alonzi T., Romani M., Fratini F., Paonessa G., Ippolito G., Tripodi M., Piacentini M. (2004) Conventional protein kinase C inhibition prevents alpha interferon-mediated hepatitis C virus replicon clearance by impairing STAT activation. J. Virol., 78, 12809-16.

Lovat P.E., Corazzari M., Goranov B., Piacentini M., Redfern C.P. (2004) Molecular mechanisms of fenretinide-induced apoptosis of neuroblastoma cells. Ann. N. Y. Acad .Sci., 1028, 81-9.

Lovat P.E., Di Sano F., Corazzari M., Fazi B., Donnorso R.P., Pearson A.D., Hall A.G., Redfern C.P., Piacentini M. (2004) Gangliosides link the acidic sphingomyelinase-mediated induction of ceramide to 12-lipoxygenase-dependent apoptosis of neuroblastoma in response to fenretinide. J. Natl. Cancer Inst., 96, 1288-99.

Perfettini J.L., Roumier T., Castedo M., Larochette N., Boya P., Raynal B., Lazar V., Ciccosanti F., Nardacci R., Penninger J., Piacentini M., Kroemer G. (2004) NF-kappaB and p53 are the dominant apoptosis-inducing transcription factors elicited by the HIV-1 envelope. J. Exp. Med., 199, 629-40.

Rodolfo C., Mormone E., Matarrese P., Ciccosanti F., Farrace M.G., Garofano E., Piredda L., Fimia G.M., Malorni W., Piacentini, M. (2004) Tissue transglutaminase is a multifunctional BH3-only protein. J. Biol. Chem., 279, 54783-92.

Vahsen N., Cande C., Briere J.J., Benit P., Joza N., Larochette N., Mastroberardino P.G., Pequignot M.O., Casares N., Lazar V., Feraud O., Debili N., Wissing S., Engelhardt S., Madeo F., Piacentini M., Penninger J.M., Schagger H., Rustin P. Kroemer G. (2004) AIF deficiency compromises oxidative phosphorylation. Embo. J., 23, 4679-89.

Lentini A., Abbruzzese A., Caraglia M., Marra M., Beninati S. (2004) Protein-polyamine conjugation by transglutaminase in cancer cell differentiation. Amino Acids, 26, 331-337.

Caraglia M., Vitale G., Marra M., Del Prete S., Lentini A., Budillon A., Beninati S., Abbruzzese A. (2004) Translational and post-translational modifications of proteins as a new mechanism of action of alpha-interferon. Amino Acids, 26, 409-417.

Cozzolino M., Ferraro E., Ferri A., Rigamonti D., Quondamatteo F., Ding H., Xu Z., Angelini D. F., Ferrari F., Rotilio G., Cattaneo E., Carrì M. T., Cecconi F. (2004) Apoptosome inactivation rescues pro-neural and neural cells from neurodegeneration. Cell Death Differ., 11, 1179-1191.

Costantino M., Caraglia M., Beninati S., Giuberti G., D’Alessandro A., Lentini A., Abbruzzese A., Bove G., Landolfi F., Rossi F., Lampa E. (2004) Alternative therapy of old earth elements increases the chondroprotective effects of chondroitin-sulfate in mice. Exp. Mol. Medicine (accettato per la pubblicazione).

1. Cozzolino M., Ferraro E., Ferri A., Rigamonti D., Quondamatteo F., Ding H., Xu Z., Angelini D. F., Ferrari F., Rotilio G., Cattaneo E., Carrì M. T. and Cecconi F. (2004) Apoptosome inactivation rescues pro-neural and neural cells from neurodegeneration. Cell death & Differ, 11, 1179-1191.

2. Cecconi F., Roth K.A., Dolgov O., Munarriz E., Anokhin K., Gruss P. and Salminen M. (2004) Apaf1-dependent programmed cell death is required for inner ear morphogenesis and growth. Development, 131, 2125-2135.

3. D’Sa C., Klocke B.J., Cecconi F., Lindsten T., Thompson C.B., Korsmeyer S.J., Flavell, R.A. and Roth, K.A. (2003) Caspase regulation of genotoxin-induced neural precursor cell death. J. Neurosci. Res., 74, 435–445.

4. Arnoult D., Gaume B., Karbowski M., Sharpe J.C., Cecconi F. and Youle R. J. (2003) Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization. Embo J., 22, 4385-4399.

5. Ferraro E., Corvaro M. and Cecconi F. (2003) Physiological and pathological roles of the apoptosome. J. Cell. Mol. Med., 7, 21-34.

6. Candé C., Cecconi F., Dessen Ph. and Kroemer G. (2002) Apoptosis inducing factor (AIF): key to the conserved caspase-independent pathways of cell death? J. Cell Sci., 115, 4727-4734.

7. Marsden V., O’Connor L., Huang D.C.S., Metcalf, D., Cecconi, F., Kuida, K., Tomaselli, K., Silke, J., Vaux, D.L., O’Reilly, L.A., Bouillet, P., Adams, J.M. and Strasser, A. (2002) Apoptosis regulated by Bcl-2 inhibition of caspase activation upstream of Apaf-1 and caspase-9. Nature, 419, 634-637.

8. Cregan, S.P., Fortin, A., MacLaurin, J.G., Callaghan, S.M., Cecconi, F., Park, D.S., Dawson, T.M., Kroemer, G. and Slack, R.S. (2002) “Apoptosis Inducing Factor Regulates Caspase-independent neuronal cell death”. J. Cell. Biol., 158, 507-517.

9. Matsuki Y., Zhang H., Hsu H., Yang P., Zhou T., Dodd C., Cecconi F., Gruss P., Tadakuma T. and Mountz J. (2002) “Different Role of Apaf-1 in Positive Selection, Negative Selection and Death by Neglect in Foetal Thymic Organ Culture”. Scand. J. Immunol., 56, 174-184.

10. Bitzer M., Armeanu S., Prinz F., Ungerechts G., Wybranietz W., Spiegel M., Bernlöhr C., Cecconi F., Gregor M., Neubert W.J., Schulze-Osthoff K. and Lauer U.M. (2002) “Caspase-8 and Apaf-1 independent caspase-9 activation in Sendai virus infected cells”. J. Biol. Chem., 277, 29817-29824.

11. O’Reilly, L. A., Harvey, N., Marsden, V., Cullen, L., Vaux, D.L., Haecker, G., Ekert, P., Magnusson, C., Pakusch, M., Cecconi, F., Kuida, K., Strasser, A., Kumar, S. and Huang, D.C.S. (2002) “Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is mediated by Apaf-1 and caspase-9”. Cell Death & Differ., 9, 832-841.

12. Heins, N., Malatesta, P., Cecconi, F., Nakafuku, M., Tucker, K.L., Hack, M.A., Chapouton, P., Barde, Y.A., Gotz, M. (2002) “Glial cells generate neurons: the role of the transcription factor Pax6”. Nat. Neurosci., 5, 308-315.

13. Moreno, S., Ferraro, E., Eckert, S. and Cecconi, F. (2002) “Apaf1 reduced expression levels generate a mutant phenotype in adult brain and skeleton”. Cell Death & Differ., 9, 340