Pubblicazioni - 2002/2004

Angelini G., Gardella S., Ardy M., Ciriolo M.R., Filomeni G., Di Trapani G., Clarke F., Sitia R., Rubartelli A. (2002) Antigen-presenting dendritic cells provide the reducing extracellular microenvironment required for T lymphocyte activation. Proc. Natl. Acad. Sci. 99, 1491-1496

p Aquilano K., Rotilio G., Ciriolo M.R. (2002) Anti- and pro-oxidant activities of Cu,Zn SOD modulate nitric oxide production. In: XI Biennal Meeting of the Society for Free Radical Research International (C. Pasquier Ed.), Monduzzi Editore, 309-313

Biroccio A., Benassi B., Filomeni G., Amodei S., Marchini S., Chiorino G., Rotilio G., Zupi G., Ciriolo M.R. (2002) Glutathione influences c-Myc-induced apoptosis in M14 human melanoma cells. J. Biol. Chem. 277, 43763-43770

Bonaccorsi di Patti, M.C., Giartosio, A., Rotilio, G., Battistoni, A. (2002) Analysis of Cu,ZnSOD conformational stability by differential scanning calorimetry. Methods Enzymology 349, 49-61

Caccuri A.M., Antonini G., Allocati N., Di Ilio C., De Maria F., Innocenti F., Parker M.W, Masulli M., Lo Bello M., Turella P., Federici G., Ricci G. (2002) GST B1-1 from Proteus mirabilis: a snapshot of an enzyme in the evolutionary pathway from a redox enzyme to a conjugating enzyme. J. Biol. Chem. 277, 18777-18784.

Casciati A., Ferri A., Cozzolino M., Celsi F., Nencini M., Rotilio G., Carrì M.T. (2002) Oxidative modulation of NF-?B in human cells expressing mutant FALS-typical superoxide dismutases. J. Neurochem. 83, 1019-1029

Castrignanò T., Chillemi G., Varani G., Desideri A. (2002) Molecular dynamics simulation of the RNA complex of a double stranded RNA-binding domain reveals dynamic features of the intermolecular interface and its hydration. Biophys. J., 83, 3542-3552

De Maria F., Pedersen J. Z., Caccuri AM., Antonini G., Turella P., Stella L., Lo Bello M., Federici
Falconi M, Parrilli L, Battistoni A, Desideri A (2002) Flexibility in monomeric Cu,Zn superoxide dismutase detected by limited proteolysis and molecular dynamics simulation. Proteins 47, 513-520

Filomeni G., Rotilio G., Ciriolo M.R. (2002) Cell signalling and the glutathione redox system. Biochem. Pharmacol. 64, 1057-1064

Fornai F., Carrì M.T., Ferri A, Paolucci E., Prisco S., Bernardi G., Rotilio G., Mercuri N.B. (2002) Resistance to striatal dopamine loss induced by MPTP in mice expressing mutant human SOD1. Neurosci. Lett 325, 124–128

Langford, P.R, Sansone, A., Valenti, P., Battistoni, A., Kroll, J.S. (2002) Methods for the study of bacterial SOD and virulence. Methods in Enzymology 349, 513-520

Lombardo M. F., Ciriolo M. R., Ciccarelli R., Rotilio G., Rossi L. (2002) Copper, oxidative stress and neurodegeneration. In: XI Biennal Meeting of the Society for Free Radical Research International (C. Pasquier Ed.), Monduzzi Editore , 271-275

Militello V., Leone M., Cupane A., Santucci R., Desideri A. (2002) Local dynamics properties of the heme pocket in native and solvent-induced molten-globule state of cytochrome c. Biophys. Chem., 97, 121-128

Mondola P., Serù R., Santillo M., Damiano S., Bifulco M., Laezza C., Formisano P., Rotilio G., Ciriolo M.R. (2002) Effect of Cu,Zn superoxide dismutase on cholesterol metabolism in human Hepatocarcinoma (HepG2) cells. Biochem. Biophys. Res. Commun. 295, 603-609

Padiglia A., Medda R., Longu S., Pedersen J.Z., Floris, G. (2002) Uric acid is a main electron donor to peroxidases in human blood plasma. Med. Sci. Monit., 8, 454-459.

Rossi L., Squitti R., Pasqualetti P., Marchese E., Cassetta E., Forastiere E., Rotilio G.,. Rossini P. M., Finazzi Agrò A. (2002). Red blood cell copper, zinc superoxide dismutase activity is higher in Alzheimer’s disease and is decreased by D-penicillamine. Neurosci. Lett., 329, 137-140

Squitti R.,. Lupoi D., Pasqualetti, P., Dal Forno G., Vernici F., Chiovenda P., Rossi L., Cortesi M., Cassetta E., Rossini P. M. (2002) Elevation of serum copper levels in Alzheimer disease, Neurology, 59, 1153-1161

Squitti R.,. Rossini P. M, Cassetta E., Moffa F., Pasqualetti P., Cortesi M., Colloca A., Rossi L.., Finazzi-Agrò A. (2002) D-penicillamine reduces serum oxidative stress in Alzheimer’s disease patients. Eur. J. Clin. Invest., 32, 51-59

Tozzi G., Nuccetelli M., Lo Bello M., Bernardini S., Bellincampi L., Ballerini S., Gaeta L.M., Casali C., Pastore A., Federici G., Bertini E., Piemonte F. (2002) Antioxidant enzymes in blood of patients with Friedreich's ataxia. Arch. Dis. Child, 86, 376-379.

Wagner W., Bielli P., Wacha S., Ragnini-Wilson A.(2002) Mlc1p promotes septum closure during cytokinesis via the IQ motifs of the vesicle motor Myo2p. EMBO. J., 21, 6397-6408

Rotilio G., Ciriolo M. R., Carrì M. T., Rossi L. (2002) Disturbances of copper homeostasis and brain function. In: Handbook of Copper Pharmacology and Toxicology (E. J. Massaro Ed.), Humana Press Inc., 277-296

Sergi A., G. Ciccotti, M. Falconi, A. Desideri, M. Ferrario (2002) Effective binding force calculation in a dimeric protein by molecular dynamics simulation. J. Chem. Phys., 116, 6329-6338.

Liuzzi F., Fanelli C., Ciriolo M.R., Cerella C., D’Alessio M., DeNicola M., Magrini A., Bergamaschi A., Ghibelli L. (2003) Rescue of cells from apoptosis by antioxidants occurs downstream from GSH extrusion. Ann. New York Acad. Sci. 1010, 441-444

Antolini F., Lo Bello M., Sette M. (2003) Purified promyelocytic leukemia coiled-coil aggregates as a tetramer displaying low alpha-helical content. Protein Expr. Purif. 29, 94-102.

Aquilano K., Rotilio G., Ciriolo M.R. (2003) Proteasome activation and nNOS down-regulation in neuroblastoma cells expressing a Cu,Zn superoxide dismutase mutant involved in familial ALS. J. Neurochem. 85, 1324-1335

Aquilano K., Rotilio G., Ciriolo M.R. (2003) Role of proteasome in counteracting reactive oxygen and nitrogen species-mediated damage in neuroblastoma cells. In: Free radicals and ossidative stress: Chemistry, biochemistry and pathophysiologique implication. (D. Galaris, Ed.) Medimond, 85-89

Battistoni A. (2003) Role of prokaryotic Cu,Zn superoxide dismutase in pathogenesis. Biochem. Soc. Trans. 6, 1326-1329

Beretta S., Carrì M.T., Beghi E., Chiò A., Ferrarese C. (2003) The sinister side of Italian soccer. The Lancet Neurology 2, 656-657

Beretta S., Sala G., Mattavelli L., Ceresa C., Casciati A., Ferri A., Carrì M.T., Ferrarese C. (2003) Mitochondrial dysfunction due to mutant copper/zinc superoxide dismutase associated with familial amyotrophic lateral sclerosis is reversed by n-acetyl-cysteine. Neurobiol. Disease 13, 213-221

Carrì M.T., Ferri A., Cozzolino M., Calabrese L., Rotilio G. (2003) Neurodegeneration in amyotrophic lateral sclerosis : the role of oxidative stress and altered homeostasis of metals. Brain Res. Bull. 61, 365-374

Chillemi G., Fiorani P., Benedetti P., Desideri (2003) A.protein concerted motions in the DNA-topoisomerase I complex. Nucleic Acids Res., 5, 1525-1535

Cioni P., Pesce A., Morozzo della Rocca B., Castelli S., Falconi M., Parrilli L., Bolognesi M., Strambini G.,Desideri A., (2003) Active-site copper and zinc ions modulate the quaternary structure of prokaryotic Cu, Zn superoxide dismutase. J. Mol. Biol., 326 , 1351-1360

De Maria F., Pedersen J. Z., Caccuri AM., Antonini G., Turella P., Stella L., Lo Bello M., Federici G ., Ricci G. (2003) The specific interaction of dinitrosyl-diglutathionyl-iron complex, a natural NO-carrier, with the glutathione transferase superfamily. J. Biol. Chem. 278, 42283- 42293.

Desideri A., Falconi M. (2003) Prokarotic Cu. Zn superoxide Dismutases. Biochem. Soc. Trans., (Pt 6), 1322-1325

Falconi M, Brunelli M, Pesce A, Ferrario M, Bolognesi M, Desideri A. (2003) Static and dynamic water molecules in Cu,Zn superoxide dismutase. Proteins, 51(4), 607-15

Filomeni G., Aquilano K., Rotilio G., Ciriolo M.R. (2003) ROS-dependent JNK/c-Jun signaling cascade mediates neuroblastoma cell death induced by diallyl disulfide. Cancer Res. 63, 5940-5949

Filomeni G., Rotilio G., Ciriolo M.R. (2003) Glutathione disulfide induces apoptosis of U937 cells by a redox-mediated p38 MAP kinase pathway. FASEB J. 17, 64-66

Fiorani P, Bruselles A, Falconi M, Chillemi G, Desideri A, Benedetti P. (2003) Single mutation in the linker domain confers protein flexibility and camptothecin resistance to human topoisomerase I. J. Biol. Chem., 278, 43268-43275

Ibarra C., Grillo MP., Lo Bello M., Nuccetelli M., Bammler TK., Atkins WM. (2003) Exploration of in vitro pro-drug activation and futile cycling by glutathione S-transferases: thiol ester hydrolysis and inhibitor maturation. Arch. Biochem. Biophys. 414, 303-11

. Lombardo M. F., Ciriolo M. R., Rotilio G., Rossi L. (2003). Prolonged copper-deplet

ion induces expression of antioxidants and triggers apoptosis in SH-SY5Y neuroblastoma cells. Cell. Molec. Life Sci. 60, 1733-1743

Medda R., Padiglia A., Longu S., Bellelli A., Arcovito A., Cavallo S., Pedersen, J.Z., Floris G. (2003) Critical role of Ca2+ ions in the reaction mechanism of Euphorbia characias peroxidase. Biochemistry, 42, 8909-8918.

Micaloni C., Kong G. K-W., Mazzetti A. P., Nuccetelli M., Antonini G., Stella L., McKinstry W. J., Polekhina G., Rossjohn J., Federici G., Ricci G., Parker M. W., and Lo Bello M. (2003) Engineering a new C-terminal tail in the H-site of human glutathione transferase P1-1: structural and functional consequences. J.Mol.Biol. 325, 111-122.

Morozzo della Rocca B., Lauria G., Venerini F., Palmieri L., Polizio F., Capobianco L., Stipani V., Cappello A.R., Desideri A., Palmieri F. (2003) The mitochondrial oxoglutarate carrier: structural and dynamical properties of thransmembrane segment IV studied by site_directed spin labeling. Biochemistry , 42, 5493-99

Nencioni L., Iuvara A., Aquilano K., Ciriolo M.R., Cozzolino F., Rotilio G., Garaci E., Palamara A.T. (2003) Influenza a virus replication is dependent on an antioxidant pathway that involves GSH and Bcl-2. FASEB J. 17, 758-760

Orsale M, Melino S, Contessa GM, Torre V, Andreotti G, Motta A, Paci M, Desideri A, Cicero D.O. (2003) Two distinct calcium-calmodulin interactions with N-terminal regions of the olfactory and rod cyclic nucleotide-gated channels characterized by NMR spectroscopy. FEBS Lett., 548, 11-16
Ortiz-Salmeron E., Nuccetelli M., Oakley AJ., Parker MW., Lo Bello M., Garcia-Fuentes L. (2003) Thermodynamic description of the effect of the mutation Y49F on human glutathione transferase P1-1 in binding with glutathione and the inhibitor S-hexylglutathione. J. Biol. Chem. 278, 46938-46948.

Ricci G., Caccuri A., Lo Bello M., Parker MW., Nuccetelli M., Turella P., Stella L., Di Iorio EE., Federici G. (2003) Glutathione transferase P1-1: self-preservation of an anti-cancer enzyme. Biochem. J. 376, 71-76.

Rossi L., Lombardo M. F., Ciriolo M. R., Rotilio G. (2003) Mitochondrial dysfunction in neurodegenerative diseases associated with copper imbalance. Neurochem. Res., 29, 493-504

Rotilio G., Aquilano K., Ciriolo M.R. (2003) Interplay of Cu,Zn superoxide dismutase and nitric oxide synthase in neurodegenerative processes. IUBMB Life 55, 629-634

Squitti R., Lupoi D., Pasqualetti P., Dal Forno G., Verzieri F., Chiovenda P., Rossi L., Cortesi M., Cassetta E., Rossini P. M. (2003). Elevation of serum copper content levels in Alzheimer’s disease. Neurology, 60, 1559

Turella P., Pedersen J.Z., Caccuri A.M., De Maria F., Mastroberardino P., Lo Bello M., Federici G., Ricci G. (2003) Glutathione transferase superfamily behaves like storage proteins for dinitrosyl-diglutathionyl-iron complex in heterogeneous systems. J. Biol. Chem. 278, 42294-42299.

van Zanden J.J., Ben Hamman O., van Iersel M.L., Boeren S., Cnubben N.H., Lo Bello M., Vervoort J., van Bladeren P.J., Rietjens I.M. (2003) Inhibition of human glutathione S-transferase P1-1 by the flavonoid quercetin. Chem. Biol. Interact. 145, 139-48.

Battistoni A. Ajello, M., Ammendola, S., Rotilio, G., and Valenti, P. (2004) Involvement of reactive oxygen species in bacterial killing within epithelial cells. Int. J. Immun. Pharm. 17, 71-76

Bendotti C., Carrì M.T. (2004) Lessons from models of SOD1-linked familial ALS. Trends Mol. Medicine 10, 393-400

Berducci G, Mazzetti AP, Rotilio G, Battistoni A (2004) Periplasmic competition for zinc uptake between the metallochaperone ZnuA and Cu,Zn superoxide dismutase. FEBS Lett. 569, 289-292

Bottini M., Di Venere A., Tautz L., Lugli P., Avigliano L., Rosato N., (2004) Structural stability of Azurin encapsulated in sol-gel glasses: a fluorimetric study. J. Sol-Gel Sci. Tech., 30, 205-214

Celsi F., Ferri A., Casciati A., D’Ambrosi N., Rotilio G., Costa A., Volonté C., Carrì M.T. (2004) Overexpression of superoxide dismutase 1 protects against beta-amyloid peptide toxicity: effect of estrogen and copper chelators. Neurochem. International 44, 25-33

Chillemi G., Redinbo M., Bruselles A., Desideri A., (2004) Role of the linker domain and the 203-214 N-terminal residues in the human topoisomerase I DNA complex dynamics. Biophys. J., 87, 1-11

Cozzolino M., Ferraro E., Ferri A., Rigamonti D., Quondamatteo F., Ding H., Xu Z.S., Ferrari F., Angelini D.F., Rotilio G., Cattaneo E., Carrì M.T., Cecconi F. (2004) Apoptosome inactivation rescues proneural and neural cells from neurodegeneration. Cell Death Differ. 11, 1179-1191

Falconi M. Melino G., Desideri A. (2004) Molecular dynamics simulation of the C-terminal sterile a motif domain of p73a: evidences of a dynamical relationship between helices 3 and 5 Biochem. Biophys. Res. Comm., 316, 1037-1042

Ferri A., Nencini M., Battistini S., Giannini F., Siciliano G., Casali C., Damiano M.G., Ceroni M., Chiò A., Rotilio G., Carrì M.T. (2004) Activity of protein phosphatase calcineurin is decreased in sporadic and familial amyotrophic lateral sclerosis patients. J. Neurochem. 90, 1237-1244

Ferri A., Nencini M., Casciati A., Cozzolino M., Angelini D.F., Longone P., Spallone A., Rotilio G., Carrì M.T. (2004) Cell death in amyotrophic lateral sclerosis: interplay between neuronal and glial cells. FASEB J. 11, 1261-1263

Foxon S.P., Torres G.R., Walter O., Pedersen J.Z., Toftlund H., Hüber M., Falk K., Haase W., Cano J., Lloret F., Julve M., Schindler, S. (2004) Syntheses, structures, and magnetic properties of copper(II) complexes with 1,3-[bis(2-pyridylmethyl)amino]benzene (1,3-tpbd) as ligand. Eur. J. Inorg. Chem., 2004, 335-343

Gabbianelli R, D’Orazio M., Pacello F, O’Neill P., Nicolini L, Rotilio G., and Battistoni A. (2004). Distinctive functional features in prokaryotic and eukaryotic Cu,Zn superoxide dismutases. Biol Chem. 385, 749-754

Gabbianelli R., Signoretti C., Marta I., Battistoni A., Nicolini L. (2004) Vibrio cholerae periplasmic superoxide dismutase: isolation of the gene and overexpression of the protein. J. Biotechnology 109, 123-130

Garofoli S., Falconi M., Desideri A., (2004) Thermophilicity of wild type and mutant cold shock proteins by molecular dynamics simulation. J. Biomol. Struct. Dyn., 21, 1-9

Lombardo M. F., Rotilio G., Ciriolo M. R., Rossi L. (2004) Copper imbalance, oxidative stress and mitochondrial damage in neuroblastoma cells. In: Free radicals and ossidative stress: Chemistry, biochemistry and pathophysiologique implication. (D. Galaris, Ed.) Medimond, Monduzzi Editore ,115-119

Longu S., Medda R., Padiglia A., Pedersen J.Z., Floris G. (2004) The reaction mechanism of plant peroxidases. Ital. J. Biochem., 53, 42-46.

Melino S., Pennestri M., Santoprete A., Bielli P., Paci M., Ragnini-Wilson A., Cicero D. O. (2004) Assignment of the 1H, 13C and 15N resonances of Mlc1p from Saccharomices cerevisiae. J. Biomol. NMR, in press

Nerini Molteni S., Fassio A., Ciriolo M.R., Filomeni G., Pasqualetto E., Fagioli C., Sitia R. (2004) Glutathione limits Ero-1 dependent oxidation in the endoplasmic reticulum. J. Biol. Chem. 279, 32667-32673

Padiglia A., Floris G., Longu S., Schininà M.E., Pedersen J.Z., De Angelis F., Finazzi Agrò A., Medda R. (2004) Tyramine oxidation by lentil copper/TPQ amine oxidase covalently modifies an essential lysine residue and the TPQ cofactor. Biol. Chem., 385, 323-329.

Rinalducci S., Pedersen J.Z., Zolla, L. (2004) Formation of radicals from singlet oxygen produced during photoinhibition of isolated light harvesting proteins of photosystem II. Biochim. Biophys. Acta, 1608, 63-73.

Rossi L., Aquilano K., Filomeni G., Lombardo M. F., Rotilio G., Ciriolo M. R. (2004) Putative mechanisms of apoptosis related to redox unbalance. In: Frontiers in neurodegenerative disorders and aging: fundamental aspects, clinical perspectives and new insights. (T. Ozben, M.Chevion Eds.), IOS Press, Washington, 207-250

Rotilio G., Canani Barba R., Branca F., Cairella G., Dilaghi B., Fieschi C., Garbagnati F., Gentile M.G., Gensini G.F., Gualtieri A., Inzitari D. La Massa M., Luisi M.L, Mancia G., Marcelli M., Masini M.L. Mastrilli F., Paouci S., Pratesi S., Rubba P., Acchetti M.L., Salvia A., Scalfi L., Scognamiglio U., Siani A., Strazzullo P. (2004) Nutritional recommendations for the prevention of ischemic stroke. Nutr. Metab. Cardiovasc. Dis., 2 , 115-120

Saulle E., Gubellini P., Picconi B., Centonze D., Troppi D., Pisani A., Morari M., Marti M., Rossi L., Papa M., Bernardi G., Calabresi P. (2004) Neuronal vulnerability following inhibition of mitochondrial complex II: a possibile ionic mechanism for Huntington’s disease. Molec. Cell. Neurosci., 25, 9-20

Spagnolo L, Toro I, D'Orazio M, O'Neill P, Pedersen JZ, Carugo O, Rotilio G, Battistoni A, Djinovic-Carugo K. (2004) Unique features of the sodC-encoded superoxide dismutase from Mycobacterium tuberculosis, a fully functional copper-containing enzyme lacking zinc in the active site. J Biol Chem., 279, 33447-33455